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Spyre Therapeutics Inc. icon

Spyre Therapeutics Inc. (SYRE NASDAQ) stock market data APIs

$102.6625 -2.34(-2.3%)
as of August 14, 2026
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Spyre Therapeutics Inc. Financial Data Overview

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Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 " anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.

Prev. Close 102.6625
Open 100.3212
High 104.8648
Low 95.6975
52 wk Range 14.505-108.14
Market Cap 8 999 M
Shares Outstanding 86 841 K
EPS -0.36
Beta 3.026

* We provide hundreds of fields of fundamental data, including EBITDA, P/E ratio, PEG ratio, trailing P/E, shareholders, insider transactions, technical metrics, dividends, splits, earnings, and more. Check out our Fundamental Data API.


ETFs with Spyre Therapeutics Inc. (top by weight)

Ticker
100-day Price Change
Weight
LFSC.US F/m Emerald Life Sciences Innovation ETF
8.72 (22.74%)
7.48
PTH.US Invesco DWA Healthcare Momentum ETF
8.92 (17.34%)
2.02
CURE.AU Global X S&P Biotech ETF
12.23 (19.3%)
1.33
XBI.MX SPDR Series Trust - SPDR S&P Biotech ETF
406.36 (17.69%)
1.33
XBI.US SPDR® S&P Biotech ETF
22.83 (16.96%)
1.29
MMSC.US First Trust Multi-Manager Small Cap Opportunities ETF
1.83 (6.68%)
1.09
FTXH.US First Trust Nasdaq Pharmaceuticals ETF
5.97 (17.63%)
1.07
GDOC.US Goldman Sachs Future Health Care Equity ETF
5.25 (16.58%)
0.89
LABU.US Direxion Daily S&P Biotech Bull 3X Shares
86.65 (45.63%)
0.83
BBC.US Virtus LifeSci Biotech Clinical Trials ETF
8.26 (18.5%)
0.79

* We provide detailed information about ETF constituents through our Fundamentals API for ETFs. Read the documentation to learn more.


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Spyre Therapeutics Inc. Fundamental data includes:

  • Net Revenue:
  • EBITDA: -207 822 000
  • Earnings Per Share: -1
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  • Latest Release: 2026-08-04
  • EPS/Forecast: -0.71
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